Syndrome (real name Buddy Pine) is a costumed supervillain and wannabe superhero who played a minor role in both the Disney vs. Non-Disney Villains tournament and the Disney Villains War. He first appeared as the main villain of the Disney/Pixar film The Incredibles.
Disney Vs Non-Disney Villains War
Syndrome comes across the human sized, Malthazar. He then makes an offer of an alliance with the evil insect, only for Malthazar to rebuff him. Humiliated, Syndrome fires an energy shot at Malthazar, though the shot toss Malthazar several feet away. He then makes his way to a cliff above Malthazar's lair, where the inscect encourages his army. The hero then drops an explosive device, that blow up the entire cavern. Syndrome leaves, assured that his enemy is pressumed dead.